A Novel Class of Tests for the Detection of Mitochondrial DNA-Mutation Involvement in Disease\par

A Novel Class of Tests for the Detection of Mitochondrial DNA-Mutation Involvement in Diseases

Details:

This program is intended to implement a test to detect mitochondrial DNA mutation involvement. The details of the methodology as well as the correct citation for this program are as follows: Sun FZ, Cui J, Gavras H, and Schwartz F. Am. J. Hum. Genet. 72 (2003) pp. 1515-1526. This program is written in C and can be compiled using standard compilers. Furthermore, each step of the program is well documented.

Code and Executables:

Pre-compiled executables:

Linux OS: mitotest_linux.rar
Unix OS:
Windows OS: mitotest_windows.rar
Mac OS:

Total Package:

mtDNA_test.zip

After downloading the package, unzip it and copy all files into the same file folder.

README file (MS Word format) contains information about the test, how to use the program and describes input/output files.

Sample Data Sets:

Sample input file:

samplepedigree.txt - contains 20 families and 199 individuals.

Results:

Sample output files:

informantlist.txt - list of informative individuals
rejectlist.txt - list of rejected/removed individuals
class.txt - reduced pedigree class information
marriedin.txt - list of all married-in relatives
familyreject.txt - list of all removed families
teststatistic.txt - summary of results

Created Date: May 2005
Last Updated Date: August 10, 2006
Contact

Fengzhu Sun, Ph.D.
Molecular and Computational Biology Program
Department of Biological Sciences
University of Southern California
Los Angeles, CA, 90089
(213) 740-2413 (phone)
(213) 740-2424 (fax)
Email: fsun AT usc DOT edu