
Our research interests are in synthetic organic chemistry and related aspects of bioorganic, combinatorial and organometallic chemistry. A central theme of this research is the study of new synthetic methods and strategies and their application to the synthesis of bioactive natural products or designed organic molecules that can lead to new materials or new pharmaceuticals. A recent focus of our work has been the exploration of new chemistry of titanium and boron, elements with diverse reactivity that are also inexpensive and environmentally safe. The synthetic work is often aided by mechanistic and computational studies, which enhance our understanding of these processes and by a variety of synthetic applications that demonstrate their synthetic utility. In this manner, the exploration of novel synthetic reactions provides the setting for discovering new chemistry, while it produces new substances for technology, biology and medicine. The preparation of new organic molecules and the collaboration with other scientists that study the physical or biological properties of these compounds allows this work to be directed at various technological or biomedical problems, such as the therapy of cancer, inflammation, etc. Since this research combines organic synthesis with organometallic, mechanistic, computational, combinatorial, biological, and medicinal chemistry, it offers a broad and multidisciplinary experience. A number of research projects are being pursued:
New chemistry of organotitanium compounds
New chemistry of organoboron compounds
New synthetic methods and strategies
New methods for combinatorial chemistry and catalysis
New chemistry of lipoxins and other lipids