Daniel O. Stram

Professor
Division of Biostatistics and Genetic Epidemiology
Department of Preventive Medicine
Keck School of Medicine

University of Southern California
1540 Alcazar Street, CHP Suite 220
Los Angeles, California 90033

Phone:  323-442-1817               
Fax: 323-442-2349        
Email:stram@usc.edu

Statistical Software
The following packages/programs are available for download. 

  1. Haplotype tagging SNP (htSNP) selection.  Implements the techniques (Stram et al 2003) used by the MEC for htSNP selection
  2.  KAPM, survival and cumulative incidence analysis with plot file generation, utilizing an interface with the plotting capabilities of EXCEL. Co-authored with Robert Gerbing of the Children’s Oncology Group
  3. Analysis of repeated ordinal data, JASA 1988
  4. The original REML program:  as implemented by Nan Laird, Nancy Cook, Daniel Stram: EM algorithm for REML estimation of the 2-level random effects model described by Laird and Ware (Biometrics, 1982)

Degrees
B.A. (Mathematics), Tufts University,1975
Ph.D. (Statistics), Temple University,1983

Boards and Committees
Member, Committee on an Assessment of CDC Radiation Studies, Commission on Life Sciences, National Academy of Sciences 1999-present

Member, Board on Radiation Effects Research, Commission on Life Sciences, National Academy of Sciences 1997-2003

Research Interests
My research is on general biostatistical issues in epidemiology, and I am a long time collaborator on a number of important prospective (cohort) studies of cancer and other diseases. These include the Atomic Bomb Survivors Study, the Multiethnic Cohort Study, and the Children's Health Study. I participate in many other projects in the Preventive Medicine Department at USC. I have particular interest in measurement error issues in dosimetry for radiation epidemiology and in dietary assessment for nutritional epidemiology. I have recently begun working on association-based testing for the influence upon cancer risk of genomic variation in candidate genes using nested case-control studies within the MEC. See the publications and software development list below, for further information.
 

Teaching
PM520  Advanced Statistical Computing  

Selected Recent Publications

1.     Stram DO, Pearce CL, Bretsky P, Freedman M, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Thomas DC. Modeling And E-M Estimation of Haplotype-Specific Relative Risks from Genotype Data for a Case-Control Study of Unrelated Individuals. Human Heredity 55:179-190, 2003.

2.     Stram DO, Haiman CA, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Pike, MC. Choosing haplotype-tagging SNPs based on unphased genotype data from a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Human Heredity  55:27-36, 2003.  

3.     Stram DO, Kopecky KJ. Power and uncertainty analysis of epidemiologic studies of radiation-related disease risk in which dose estimates are based on a complex dosimetry system: some observations. Radiation Research 160:408-417, 2003.

4.     Stram DO, Huberman M, Wu A. Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiological studies of lung cancer in smokers? American Journal of Epidemiology, 155:622-28, 2002. Power Point presentation

5.     Stram DO, Hankins JH, Wilkens LR, Pike MC,  Monroe KR, Park S, Henderson BE, Nomura AMY, Earle ME, Nagamine FS, Kolonel LN. Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. American Journal of Epidemiology, 151:371-4, 2000. 

6.     Stram DO, Langholz B, Huberman M, Thomas DC. Correcting for exposure measurement error in a reanalysis of lung cancer mortality for the Colorado Plateau uranium miners cohort. Health Physics 77:265-275, 1999.

 

Family

  1. Pavlova Stram
  2. Alex H. Stram
  3. Douglas A. Stram

Other Information

  1. Biosketch (& Support pages)
  2. Full Publication List